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Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 176-184 doi: 10.1007/s11684-021-0885-y

Abstract: Studies of human and mammalian have revealed that environmental exposure can affect paternal health conditionsby reviewing relevant literature, this study intends to answer the following research concepts: (1) paternalthat can be passed on to offspring and are attributed to spermatozoal sncRNAs, (2) potential role of paternalspermatozoal sncRNAs during the intergenerational inheritance process, and (3) the potential mechanismby which spermatozoal sncRNAs meditate intergenerational inheritance.

Keywords： small noncoding RNAs epigenetic inheritance paternal intergenerational inherence extracellular vesicles